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AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ!

 AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ! Alzheimer's diseases: New discovery on plasma Aβ42/Aβ40.  AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ! Amyloid β (Aβ) plaque deposition and phosphorylated tau (p-tau) protein tangles are two important pathological features of Alzheimer's disease (AD), and there are many kinds of AD biomarkers derived around them, Knowledge of the longitudinal trajectories of key markers could not only help improve the selection and monitoring of participants in clinical trials, but also help identify those at high risk for neurodegenerative changes and cognitive impairment.   Although research on AD biomarkers has increased substantially in recent years, research on longitudinal changes in biomarkers is relatively limited. Studies have shown that the levels of plasma Aβ 42 /Aβ 40 , p-tau181 and glial fibrillary acidic...

10% of American children suffer from fatty liver, added sugar may be the culprit

10% of American children suffer from fatty liver, added sugar may be the culprit



Recently, the "Child Obesity" magazine published an article that added sugar can bring a series of health risks to children. Excessive fructose is closely related to the increase in the incidence of non-alcoholic fatty liver (hereinafter referred to as fatty liver) in children. Eat more Dairy products help children’s liver health.





According to Sarah Anzlovar, a registered dietitian in Boston, 10% of children or adolescents in the United States suffer from fatty liver, which is the most common chronic liver disease in children. The disease does not initially exhibit any special symptoms. As the disease progresses, fatigue, yellowing of the skin or eyes, and swelling of the abdomen may occur. Over time, the liver may stop working normally, causing a series of major health problems.


Genetics may increase the risk of fatty liver in children, and excessive intake of saturated fat, cholesterol and sucrose can also lead to an increased incidence of fatty liver. This study shows that fructose and glucose are generated after sucrose is decomposed. Fructose is the most closely related to the incidence of fatty liver in children, which is the main component of added sugar.


Fructose is a sugar widely found in fruits, vegetables and honey, but it is also the main component of high fructose corn syrup. High fructose corn syrup is an artificial sweetener that can be used to make sweet drinks, canned fruits and packaged desserts. It is also a favorite food for children. According to data from the American Academy of Pediatrics, American children consume an average of 19 teaspoons of added sugar per day, which is more than three times the 6 teaspoons per day recommended by the American Heart Association.


Anzlovar suggested that the best way to reduce children's added sugar intake is to limit sugary drinks, including sodas and fruit drinks, and eat less sweets. The most vigilant thing is the added sugar in packaged foods, such as cereals, snacks, etc. Foods containing added sugars not only bring in excessive calories, but also squeeze the intake of other nutritious and beneficial foods.


Of course, although fruit contains fructose, fruit intake should not be overly restricted, because while ingesting sugar, it also consumes a large amount of nutrients such as vitamins, minerals and dietary fiber.


Dr. Moises Torres-Gonzalez, vice chairman of nutrition research of the National Dairy Council, added that in order to reduce the risk of fatty liver, children can also eat more whole-fat and low-fat dairy products. Recent studies in the Journal of Pediatric Gastroenterology and Nutrition have found that they can reduce liver fat content in children with fatty liver and have a certain liver protection effect.


The latest US dietary guidelines (2020-2025) point out that the diet of children under two years old should be free of added sugars, children over two years old should strictly limit the intake of added sugars, and adults should also limit the daily caloric intake of added sugar Below 10%. In addition to reducing the risk of diabetes, obesity and cardiovascular disease, avoiding fatty liver is also an important reason for refusing to add sugar.

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