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AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ!

 AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ! Alzheimer's diseases: New discovery on plasma Aβ42/Aβ40.  AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ! Amyloid β (Aβ) plaque deposition and phosphorylated tau (p-tau) protein tangles are two important pathological features of Alzheimer's disease (AD), and there are many kinds of AD biomarkers derived around them, Knowledge of the longitudinal trajectories of key markers could not only help improve the selection and monitoring of participants in clinical trials, but also help identify those at high risk for neurodegenerative changes and cognitive impairment.   Although research on AD biomarkers has increased substantially in recent years, research on longitudinal changes in biomarkers is relatively limited. Studies have shown that the levels of plasma Aβ 42 /Aβ 40 , p-tau181 and glial fibrillary acidic...

Acute myocardial infarction, the survival rate is less than 1%! "Sneak attack" to prevent myocardial infarction in spring

Acute myocardial infarction, the survival rate is less than 1%! "Sneak attack" to prevent myocardial infarction in spring


Spring turns warm season is acute myocardial infarction period of high , cold air is the culprit trigger angina, myocardial infarction and other cardiovascular diseases.



 

Why does myocardial love "sneak attack" in the spring?

The temperature is volatile

Hot and cold weather can easily cause vasospasm.

Some elderly people suffer from coronary heart disease themselves, and sudden changes in climate can easily induce angina pectoris and sudden myocardial infarction.

Many outdoor activities, high oxygen consumption

As the climate gets warmer, people's outdoor activities begin to increase, and myocardial oxygen consumption also increases.

Some people's heart does not adapt to the load from the resting phase to the active phase. In addition, some people do not have a good grasp of the amount of activity, and the amount of activity is too large, which is easy to induce angina or myocardial infarction.

Pandemic induced cardiovascular disease

Spring is a frequent period of various epidemic diseases, and respiratory diseases such as colds, fevers, and lung infections are prone to occur. These diseases may induce or aggravate cardiovascular diseases.


Prevent myocardial infarction, these 4 thoughtful words and listen well

01 MI symptoms, chest pain, do not ignore!

Chest pain is indeed a common sign of myocardial infarction, but it should be noted that there is a difference between men and women . The study found:

① Acute myocardial infarction in men: persistent chest pain and profuse sweating are more common;

② Female acute myocardial infarction: Female patients with myocardial infarction have less typical symptoms such as chest pain and profuse sweating than men, while radiating pain, nausea, vomiting, shortness of breath, fatigue, persistent back pain, persistent upper abdominal pain, and large and urinary incontinence are more common. common.

③ elderly patients with acute myocardial infarction attack: With increasing age, the typical symptoms of myocardial infarction share has declined, and shortness of breath, persistent upper abdominal pain and other symptoms of atypical increase in proportion.

Generally, chest pain Chaoguo 5 Fenzhong , even 20 minutes have not ease , we must be careful whether MI!

02 "The sickness is in the heart, but the pain is elsewhere"!

Typical symptoms of myocardial infarction is severe chest pain, but about Sancheng patients with myocardial infarction and no "chest pain" symptoms, usually upper abdominal pain, toothache, sore throat, dizziness, headache, neck pain, leg pain , Mild cough and shortness of breath, etc., because of atypical symptoms, it is easy to be confused with other diseases, thus delaying treatment.


According to statistics, more than half of patients with myocardial infarction did not know that they might have had a myocardial infarction at the time of the onset. Therefore, it is particularly important to understand these early warning signs before the occurrence of myocardial infarction!

In addition to the typical manifestations of myocardial infarction, it may also be "sickness in the heart, pain in other places" , this kind of pain is called "radiating pain".

● Cardiogenic toothache: It is also a clinical symptom of myocardial ischemia, the pain point is uncertain, and the pain is severe, which cannot be relieved by painkillers.

● Throat pain: paroxysmal pain in the pharynx, tightness in the neck, unsmooth breathing, often accompanied by sweating.

● Neck pain: Pain in the neck on both sides, followed by palpitations and shortness of breath.

● Lower limb pain: severe pain in the lower limb with chest tightness.

● Cough and wheezing: Coughing, wheezing, and easy to be confused with respiratory diseases.

● "Painless" myocardial infarction: In some elderly people, diabetic patients, or people who smoke a lot for a long time, the nervous system is less sensitive to pain, and there may be no chest pain, chest tightness, shortness of breath and other symptoms when a sudden myocardial infarction occurs, but it is manifested as The complexion is pale, blood pressure drops and even shock.


Normal physical examination, must pay attention to good blood lipids

" The reason for the 77% increase in mortality from coronary heart disease in Chinese is due to elevated cholesterol. Among the many risk factors, abnormal cholesterol indicators are independent and important for coronary heart disease, myocardial infarction, sudden cardiac death, and ischemic stroke. The risk factors of the disease.” The expert said.

Residents should be checked for blood lipids on a regular basis , and they should know their low-density lipoprotein cholesterol levels in time to assess their risk of disease and achieve early detection and early treatment.

① Over 20 years old: measure blood lipids at least once every 5 years.

② Men over 40 years old and postmenopausal women: blood lipids are measured every year.

③ Patients with ischemic cardiovascular disease and other high-risk groups: measure blood lipids every 3-6 months.

04Myocardial infarction is a life sickness, good habits are very important


According to the "Chinese Expert Consensus on Primary Prevention of Cardiovascular Disease" recommendations:

① The diet should be low in salt, fat and sugar.

② Drink some water before going to bed and after getting up in the morning .

③Refusing to stay up late and being over-stressed is detrimental to cardiovascular health.

④Strong tea and cigarettes will damage the cardiovascular endothelium and cause arteriosclerosis.

⑤ People with coronary heart disease, diabetes, and hyperlipidemia, especially should not overeating.

⑥ It is best to have more than 30 minutes of aerobic exercise every day. Adjust when you feel tired, don't force it.

⑦To maintain a cheerful mood.

3

Myocardial infarction first aid must pass the "three barriers"

  • MI aid should keep in mind the two "120"
  • Promptly call 120 emergency calls
  • Grasp the gold for 120 minutes

If myocardial infarction occurs, how can I help myself or others?

Remember, these three emergency passes.

The first pass is also the most critical one.

People with risk factors for myocardial infarction have chest pain and other symptoms of myocardial infarction. Once they develop symptoms, they should stop any activities immediately, take 1 tablet of nitroglycerin under the tongue, and call the emergency number immediately;

The second pass refers to the emergency center quickly dispatching ambulances to quickly transport patients to hospitals with relevant treatment capabilities;

The third hurdle is that after the patient comes to the hospital, emergency department, cardiology and other related specialists quickly diagnose and treat, and strive to allow the patient to receive reperfusion therapy within 120 minutes of onset.


Finally remind again

Once myocardial infarction occurs

Be sure to first call 120 for help

time is life

Experts advise: never seek medical treatment by yourself

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