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AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ!

 AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ! Alzheimer's diseases: New discovery on plasma Aβ42/Aβ40.  AD: Shocked! The peak value of plasma Aβ42/Aβ40 began to decline 41 years before the deposition of brain Aβ! Amyloid β (Aβ) plaque deposition and phosphorylated tau (p-tau) protein tangles are two important pathological features of Alzheimer's disease (AD), and there are many kinds of AD biomarkers derived around them, Knowledge of the longitudinal trajectories of key markers could not only help improve the selection and monitoring of participants in clinical trials, but also help identify those at high risk for neurodegenerative changes and cognitive impairment.   Although research on AD biomarkers has increased substantially in recent years, research on longitudinal changes in biomarkers is relatively limited. Studies have shown that the levels of plasma Aβ 42 /Aβ 40 , p-tau181 and glial fibrillary acidic...

194 countries and economies have begun to vaccinate, the U.S. has over 20,000 cases of mutated new coronavirus infections

194 countries and economies have begun to vaccinate, the U.S. has over 20,000 cases of mutated new coronavirus infections




The latest data released by the World Health Organization on the 9th showed that as of 17:17 on the 9th Central European Time (23:17 Beijing time), the number of confirmed cases of new coronary pneumonia worldwide increased by 733,397 compared with the previous day, reaching 133,552,774; the number of deaths increased 12924 cases, reaching 2894295 cases.


WHO Director-General Tedros Adhanom Ghebreyesus pointed out at a regular press conference for the new crown pneumonia on the 9th that 194 countries and economies have started to receive the new crown vaccine, and 26 countries and economies have not yet started vaccination. In the past six weeks, the "New Coronary Pneumonia Vaccine Implementation Plan" has provided more than 38 million doses of COVID-19 vaccine to more than 100 countries and economies.






Americas: Over 20,000 cases of mutated new coronavirus infection are reported across the United States


According to statistics from Johns Hopkins University in the United States, as of 8:21 on the 10th, Beijing time, the cumulative number of confirmed cases in the United States reached 31080839, and the cumulative number of deaths reached 561,038.


The latest data from the Centers for Disease Control and Prevention of the United States shows that as of the 8th, 20,412 cases of mutated new coronavirus infections have been reported across the United States, of which 19554 were infected with the B.1.1.7 mutated virus found in the UK, and 424 cases were infected with the B.1.351 mutation found in South Africa. Virus, there are 434 cases of infection with the P.1 mutant virus found in Brazil. Public health experts worry that many people in the United States travel and gather with relatives and friends during the spring break. Once they relax their vigilance, the epidemic may rebound.


According to data from the Brazilian Ministry of Health website, as of April 9 local time, the cumulative number of confirmed cases in Brazil reached 13,373,174, an increase of 93,317 from the previous day; the cumulative number of deaths was 348,718, an increase of 3,693 from the previous day. Reuters reported that Brazil has become the epicenter of the global epidemic, and the number of deaths from the new crown in a single day accounts for more than a quarter of the new deaths in a single day in the world. This is the "biological Fukushima nuclear accident." Experts believe that Brazil's entry into autumn and winter is more conducive to the spread of the virus. In addition, Brazil's discovery of the first confirmed case of the new crown variant strain found in South Africa is also a new danger signal.




Europe: Germany will amend the law to unify the epidemic prevention and control orders of the states


German Federal Government Deputy Spokesperson Demer said on the 9th that in order to unify the social restrictions of the states to control the new crown epidemic, the federal government will further amend the "Infectious Disease Prevention and Control Act."


Currently, Germany is experiencing the third wave of the new crown epidemic. According to data released by the Robert Koch Institute, a German disease control agency, as of 0:00 on the 9th, there were 25,464 newly confirmed cases in Germany in the past 24 hours, and the number of newly confirmed cases in a single day increased by more than 3,500 compared with a week ago. German Health Minister Span said earlier on the 9th that the number of severe cases of the new crown in Germany is rising sharply, and tough lockdown measures are needed to contain this wave of epidemics.


The Russian Epidemic Prevention Headquarters reported on the 9th that there were 9,150 new confirmed cases and a total of 4,623,984 confirmed cases; 402 new deaths and a total of 102,247 deaths. The Director of the Russian Federation Consumer Rights Protection and Public Welfare Supervision Agency Popova told the media on the 9th that when 60% of the population has completed the new crown vaccination, Russia will cancel all epidemic prevention policies. She called on citizens to actively vaccinate and remain vigilant against the spread of the virus.


According to data released by the Hungarian New Crown Epidemic Prevention and Control Center on the 9th, there were 7,325 newly confirmed cases in the country, and a total of more than 700,000 confirmed cases, reaching 705815; 285 new deaths and a total of 22,966 deaths; a total of 420,275 cases were cured. Hungarian Prime Minister Orban said in an interview with local media on the 9th that the number of people vaccinated in the country will soon reach 3 million. Currently, more than 4 million people registered on the government website will be vaccinated in early May.




Asia: Cambodia sets a record for new cases in a single day


The Ministry of Health of Cambodia announced on the 9th that there were 576 new confirmed cases in the country, a record high in the number of new cases in a single day since the outbreak. The report stated that the newly confirmed cases were all community infections, of which 544 cases were concentrated in the capital, Phnom Penh. Due to the rapid spread of the epidemic, the Cambodian government urgently requisitioned a number of schools for renovation and centralized treatment of confirmed patients.


According to statistics, as of the 9th, Cambodia had a total of 3,604 confirmed cases, a total of 24 deaths, and a total of 1984 cured. In order to control the spread of the epidemic, the spokesperson of the Cambodian Ministry of Health, Owanddin, called on people to stay at home and not go out unless necessary during the upcoming Cambodian New Year from April 14 to 16. Prior to this, Phnom Penh had implemented a two-week curfew from April 1st, from 20 o'clock to 5 o'clock the next day.


According to a report from the South Korean Central Anti-epidemic Countermeasures Headquarters on the 10th, South Korea had 677 new confirmed cases of infection compared with the previous day, and a total of 108,945 confirmed cases.


The South Korean government stated on the 9th that it is currently in the early stage of the fourth pandemic of the new crown epidemic in South Korea, and the number of new confirmed cases in a single day in the next one or two weeks is likely to increase exponentially. South Korean Prime Minister Ding Shikyun announced on the 9th that the current anti-epidemic response measures and the ban on gatherings of more than 5 people will be extended for three weeks to May 2; entertainment venues in the capital area and Busan, where the epidemic situation is severe, will be closed.




Africa: WHO's African regional officials call for a fair distribution of vaccines


Statistics from the African Centers for Disease Control and Prevention website show that as of the 8th Eastern African Time, 4,320,626 confirmed cases have been reported in Africa, with a total of 114,966 deaths. Currently, the top few countries in Africa with cumulative confirmed cases include South Africa, Morocco, Tunisia, Egypt, and Ethiopia. Among them, South Africa is the country with the largest cumulative number of reported confirmed cases and deaths.


On the evening of the 8th, the World Health Organization's African Regional Director Macki Disomuti issued a statement in Nairobi, the capital of Kenya, saying that up to now, the number of vaccinations in African countries has only accounted for 2% of the global total. WHO statistics show that 45 African countries have started vaccination work, but affected by medical, cold chain, logistics and other conditions, the distribution of vaccines in Africa is not balanced. Among them, 10 countries have obtained 93% of the vaccine in Africa. Vaccine.


Muti said that limited vaccine stocks and supply bottlenecks have prevented many people in African countries from obtaining vaccines, and if the world is to defeat the new crown epidemic, vaccines must be distributed fairly.




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